Project Summary

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Epidemiological modelling is an important tool to help public health planners understand potential disease outcomes in the population. The recent visibility of models and their perceived influence in the decision-making processes surrounding the response to the COVID-19 pandemic has led to a great deal of public debate about their usefulness [1, 2]. Making optimal use of these models to inform decisions requires addressing the hurdles that prevent it. These hurdles include the technical aspects of modelling such as identifying relevant parameters, making realistic assumptions for e.g., counterfactual scenarios, availability and quality of local data, adherence to guidelines, and review process, among others. Equally important is the environment surrounding modelling to policy exercise which includes infrastructure that informs models for e.g., surveillance and local data collection, governance and working relationships between decision-makers, their advisors, modellers, field epidemiologists among other interdisciplinary experts, ways in which results are made available and communicated to end-users, etc.

Frameworks currently exist to ensure the models are fit-for-purpose, reliable results are reported in a timely manner, and a collaborative approach to modelling ensures adequate representation from other experts [3]. Nonetheless, several gaps exist including how policy questions are accurately translated into modelling questions to ensure outputs are relevant, how multidisciplinary experts engage in the model development and review process, and how model results and subsequent decisions are effectively communicated for better policy implementation and adherence [4].

Hence, this proposed Lancet Commission will focus to identify and address some of those gaps to improve the usefulness and impact of epidemiological modelling on policymaking and policy implementation.

This commission is being supported by the Bill & Melinda Gates Foundation (BMGF) and the Access and Delivery Partnership (ADP) – hosted by the United Nations Development Programme (UNDP).

Disclaimer: The findings and conclusions contained within are those of the authors and do not necessarily reflect positions or policies of the Bill & Melinda Gates Foundation.


The list of Commissioners is as follows:


  1. Mark Jit, PhD
  2. Wanrudee ‘Mink’ Isaranuwatchai, PhD


  1. Edwine Barasa, PhD
  2. Alex R. Cook, PhD
  3. Zulma M. Cucunuba, MD, PhD
  4. Janan Dietrich, PhD
  5. Ruth R. Faden, PhD
  6. Gabriel M. Leung, MD, MPH
  7. Stephen Lim, PhD
  8. Marc Lipsitch, DPhil
  9. Rachel Lowe, PhD
  10. Jodie McVernon, MBBS, PhD
  11. Gautam Menon, PhD
  12. Juliet Pulliam, PhD
  13. Yot Teerawattananon, MD, PhD
  14. Erica Thompson, PhD


  1. Crystal Chua, BCom
  2. Hannah Clapham, PhD
  3. Saudamini Dabak, MA
  4. David Heymann, MD, DTM&H, CBE
  5. Sarin K C, MSc
  6. Jennifer Kealy, MPH
  7. Chris Mercado, RN, MPH, MSc
  8. Chayapat ‘Prayfa’ Rachatan, BSc

The planned activities are as follows:



  1. Holmdahl, I. and C. Buckee, Wrong but Useful — What Covid-19 Epidemiologic Models Can and Cannot Tell Us. New England Journal of Medicine, 2020. 383(4): p. 303-305.
  2. James, L.P., et al., The Use and Misuse of Mathematical Modeling for Infectious Disease Policymaking: Lessons for the COVID-19 Pandemic. Med Decis Making, 2021. 41(4): p. 379-385.
  3. Teerawattananon, Y., et al., Recalibrating the notion of modelling for policymaking during pandemics. Epidemics, 2022. 38: p. 100552.
  4. Kretzschmar, M., Disease modeling for public health: added value, challenges, and institutional constraints. Journal of Public Health Policy, 2020. 41(1): p. 39-51.