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A protocol for a systematic literature review of economic evaluation studies of interventions to address antimicrobial resistance

Abstract Background Antimicrobial resistance (AMR) is accelerated by the widespread and often indiscriminate use of antimicrobials in humans, animals, and the environment. In 2015, the World Health Organization recognised AMR as one of the top ten global health threats, due to its potential to n

Using an experiment among clinical experts to determine the cost and clinical impact of rapid whole exome sequencing in acute pediatric settings

Introduction Genetic disorders in children contribute to acute hospitalizations and mortality. Early diagnosis is critical for better outcomes but difficult to achieve due to atypical presentations for thousands of potential genetic diseases. Next-generation sequencing (NGS) is a precision

Assessing the Value for Money of Enzyme Replacement Therapy in Gaucher Disease Types 1 and 3b: Can Expanded Coverage Be Justified?

Abstract Background and Objectives The Health Intervention and Technology Assessment Program was commissioned to conduct a cost–utility and budget impact analysis of enzyme replacement therapy (ERT) for Gaucher disease types 1 and 3b. The findings from this assessment are to support the decision-m

Assessing the Value for Money of Enzyme Replacement Therapy in Gaucher Disease Types 1 and 3b: Can Expanded Coverage Be Justified?

Abstract Background and Objectives The Health Intervention and Technology Assessment Program was commissioned to conduct a cost–utility and budget impact analysis of enzyme replacement therapy (ERT) for Gaucher disease types 1 and 3b. The findings from this assessment are to support the decision-m

Value Distribution in New Branded Medicines: How Much Benefits Patients Versus Manufacturers?

Thailand has successfully implemented economic evaluation to inform the inclusion of new, branded medicines within its National List of Essential Medicines (NLEM). This method can be used to assess the health value that new medicines will generate for patients after accounting for the health los

Strategies for Sustainable Access: Unpacking Managed Entry Agreements (MEAs) and Innovative Medicine Access

MEAs aim at early access to high-cost innovative medicines at pre-determined terms that can ensure the financial sustainability of healthcare systems. However, their successful adoption hinges on a consideration of various factors to address the unique challenges faced by different nations. The a

Radiation Concerns Rise With Patients’ Exposure

Even in health care systems in which doctors do not bill for each test they administer, the use of diagnostic imaging like CT and PET scans has soared, as has patients’ radiation exposure, a new study has found.The study, published online on Tuesday in The Journal of the American Medical Association

Sept. 11 Health Fund Given Clearance to Cover Cancer

A federal health official’s ruling has cleared the way for 50 different types of cancer to be added to the list of sicknesses covered by a $4.3 billion fund set up to compensate and treat people exposed to the toxic smoke, dust and fumes in the months after the Sept. 11, 2001, terrorist attacks.The

The Trouble With ‘Doctor Knows Best’

Doctors were told last month that we should stop doing so many screenings for prostate cancer with the prostate-specific antigen test. We learned that sigmoidoscopy is a cheaper, easier and effective alternative to colonoscopy for colon cancer screening. And a study I led turned up strong evidence t

In Study, Drug Delays Worsening of Breast Cancer, With Fewer Side Effects

CHICAGO — A drug that delivers a powerful poison to tumors without some of the side effects of traditional treatments can delay the worsening of breast cancer and also appears to substantially prolong lives, according to results of a study presented here Saturday.Besides representing an advance in t
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