The objective of this study is to promote the rational drug use of Thailand. E List, clause 2 for specific patients is added in the National List of Essential Medicines, 2551 B.E. Ten medicines, which require knowledge, specialization in disease or advanced technology, are included in the list. However, it is likely that the prescription of these medicines is not justified. Since the medicines are costly, the prescription has a dramatic effect on the ability to pay for both the patients and society as a whole. This study evaluated the principle and policy development process of E List, clause 2, management mechanism in national and agency levels, as well as health outcomes and health economics.