Abstract BACKGROUND: Recently, the second-generation tyrosine kinase inhibitors dasatinib and nilotinib have emerged as alternative treatments in patients with chronic myeloid leukemia (CML) who are resistant to or intolerant of imatinib. OBJECTIVE: This article aimed to assess the cos

Imatinib, the first tyrosine kinase inhibitor (TKI) has been used widely as a first-line treatment for newly diagnosed CML patients. Approximately 20-30% of CML patients are resistant or intolerant to the drug, and half of these cases are due to a gene mutation in the ABL domain. Recently, second generation TKIs have emerged, such as dasatinib and

The objective of this study is to analyze the impact on the national budget of Chemotherapy as adjuvant therapy. The costeffectiveness and cost-utility of providing adjuvant therapy for stage III colorectal cancer patients were estimated. The regimens with and without Oxaliplatin for stage III colorectal cancer patients were compared. The 5-Fluorou

Background: In Thailand, there has been no economic evaluation study of adjuvant chemotherapy for stage III colon cancer patients after resection. Objective: This study aims to evaluate the cost-utility of all chemotherapy regimens currently used in Thailand compared with the adjuvant 5-fluorouracil

The objective of this study is to estimate the cost-utility analysis of the cholinesterase inhibitors (i.e., donepezil, galantamine and rivastigmine) compared with no drug treatment in patients with mild to moderate alzheimer’s disease (AD) in Thailand based on the societal and governmental perspectives and to estimate the budget impact of the ch

Cost-utility analysis of 10- and 13-valent pneumococcal conjugate vaccines: Protection at what price in the Thai context? Wantanee Kulpenga, b, , , , Pattara Leelahavaronga, , Waranya Rattanavipaponga, , Vorasith Sornsrivichaib, , Henry C. Baggettc, , Aronrag Meeyaia, d, , , Warunee Punpaniche, ,

A model-based economic evaluation was performed to estimate costs as well as outcomes of vaccination with PCV10 and PCV13 compared to ‘no vaccination’. This study considered two commonly recommended regimens: two-dose primary series at 2 and 4 months of age plus a booster dose at age 13 months (2+1) and three-dose primary series at 2, 4 and 6 m

Familial Hypercholesterolemia (FH) is a genetic disorder characterized by elevated cholesterol levels, significantly increasing the risk of heart disease. Early detection through genetic screening can play a crucial role in preventing serious health outcomes. This study marks the first global eco

Systemic sclerosis (SSc) patients often become refractory to proton pump inhibitors (PPI)—a standard treatment for gastroesophageal reflux disease (GERD)—and intolerant to PPI in combination with domperidone. PPI with alginic acid is an alternative treatment option, but alginic acid is costly. We

ABSTRACT Objective Despite treatment availability, chronic hepatitis C virus (HCV) public health burden is rising in India due to lack of timely diagnosis. Therefore, we aim to assess incremental cost per quality-adjusted life year (QALY) for one-time universal screening followed by treatment of